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Those patients with immune-related disorders such as HIV or are allergic to lidocaine are also not candidates

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PMID: 23016101 Marimuthu K et al

Mechanistic Studies Subsequent research has explored the mechanisms by which NNMT regulates metabolism, with studies demonstrating that NNMT activity reduces cellular NAD+ availability, affects SAM-dependent methylation reactions, modulates sirtuin activity, and influences adipocyte differentiation and function